R. Logan Murphy
RL.Murphy19@proton.me (703) 999-4340
Experience
Acting Instructor/Research Scientist 3
University of Washington, Seattle, WA
Feb 2023 – Mar 2025
PROJECTS:
1) Develop novel electrical stimulation protocols to treat spasticity after spinal cord injury.
A multidisciplinary collaboration between multiple spinal cord injury labs at the University of Washington. Our goals were to identify a spinal stimulation protocol that would specifically target spinal reflex pathways and restore them to a pre-injury like state.
Responsibilities
– Train and supervise junior lab members to conduct experiments
– Identify and test potential novel electrical stimulation therapeutics
– Develop implants and surgical techniques necessary for peripheral nerve implantation and spinal implantation
-Develop tools to analyze spinal reflex electrophysiology data with Python
2) Analyze the changes in psychology/emotion and pain processing after cervical spinal cord injury.
This project was designed and motivated by previous experiments that I had conducted in the lab that identified significant sex-differences in recovery after cervical spinal cord injury. We wanted to know if depression or anxiety-like behaviors or sex differences in pain signaling were significant factors influencing recovery.
Responsibilities
– Design experiments to evaluate emotional and pain responses after spinal cord injury
-Select potential anxiolytic compounds
– Coordinate experiments with multiple lab members
Postdoctoral Researcher (Senior Fellow)
University of Washington, Seattle, WA
Feb 2018 – Mar 2023
PROJECT:
Develop a novel closed loop electrical stimulation therapeutic, targeted activity-dependent spinal stimulation, for the treatment of cervical spinal injury.
This project was my introduction to spinal cord injury. We were motivated by previous work in the lab (Mcpherson, 2015) to advance a closed-loop brain-computer-interface spinal stimulation protocol. We wanted to optimize the therapeutic protocol (duration, number of concurrent-closed loops) and evaluate males vs. females in recovery.
Responsibilities:
– Conduct experiments implemented closed-loop electrical stimulation for recovery of hand and arm function after cervical spinal cord injury.
-Conduct a highly detailed evaluation of multiple aspects of recovery (fine motor control, strength, range of motion, and locomotion)
-Test duration of therapy needed for long-term robust recovery
-Evaluate the novel therapy in males and females
Education
George Mason University, School of Systems Biology
Ph.D., Biosciences – Cell and Molecular Biology Concentration.
Aug 2010 – Dec 2017
Project:
– Adolescent nicotine consumption in relation to social interactions, cd81 gene function, and mesocorticolimbic gene expression
Techniques:
– Molecular (gene expression & protein arrays) and behavioral Assays
– DNA, RNA, and protein isolation
– PCR and qPCR
– Protein Westernblots and Protein Arrays
– Automated mouse behavioral analysis
– Transgenic mouse colony maintenance, breeding, and genotyping
James Madison University
B.S., Biotechnology
Aug 2006 – May 2010
Northern Virginia Community College
A.A., Liberal Arts
Aug 2004 – Aug 2006
Manuscripts
RL Murphy, A Sadeghi, SI Perlmutter, C Hoffsteter, C Moritz. Differential modulation of cervical spinal reflexes with common open-look spinal stimulation frequencies. Submitted.
RL Murphy, SI Perlmutter. Targeted, Activity dependent spinal stimulation mediated Recovery from cervical spinal cord injury is sex dependent. In preparation.
RL Murphy, A Sadeghi, SI Perlmutter, C Hoffsteter, C Moritz. Differential modulation of cervical spinal reflexes with common open-look spinal stimulation frequencies. In preparation.
BR Kondiles, RL Murphy, AJ Widman, SI Perlmutter, PJ Horner. Cortical Stimulation leads to shortened myelin sheaths and increased axonal branching in spared axons after cervical spinal cord injury. Glia. 2023
Larry E Shupe, Frank P Miles, Geoff Jones, Richy Yun, Jonathan Mishler, Irene Rembado, R Logan Murphy, Steve I Perlmutter, Eberhard E Fetz. Neurochip3: an autonomous multichannel bidirectional brain-computer interface for closed-loop activity-dependent stimulation,. Frontiers in Neuroscience. 2021
RL Murphy, LL Locklear, MH Niaz, RL Walton, AD Hudson, KJ Fryxell. Nicotine preference and affective behavior of Cd81 knockout mice. Psychopharmacology. 2021